Protein-Protein Interactions (PPI) & RIPTAC induced Ternary Complex Assays

AlphaLISA™ SureFire® technology has become the industry benchmark for cell-based assays. Originally developed for the measurement of endogenous protein phosphorylation, the portfolio now comprises around 700 assays enabling the detection of a wide range of cellular events, including protein dimerization, aggregation, degradation, and beyond. The platform has recently been adapted for the detection of endogenous PPI and RIPTAC-induced ternary complexes, further extending its utility in studying complex cellular mechanisms and targeted therapeutic modalities.

Technology

SureFire® Products

TGR’s flagship product range, AlphaLISA SureFire® Ultra™, caters for the high throughput analysis of cell-based proteins using a no-wash, bead-based technology and this extensive range of assays (>500) are widely used by pharmaceutical/biotech companies for drug discovery research. More recently, TGR has expanded its CaptSure™ technology to multiplexing with its application to SureFire® Ultra™ Multiplex.

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Technology

Our CaptSure™ platform technology is highly amenable to multiplexing applications. TGR’s expanded platform of CaptSure™ anti-peptide antibodies can be used in various immunoassay formats such as bead-based assays, ELISA, lateral flow, immunohistochemistry and microfluidics for single or multiplex detection of analytes.

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The technology has applications in bead-based assays, ELISA, lateral flow, and microfluidics for both life sciences and diagnostics markets

TGR’s flagship product range, SureFire® Ultra™, caters for high throughput analysis of phosphoproteins using a no-wash, bead-based technology.

TGR has expanded its CaptSure™ technology to multiplexing with its application to SureFire® Ultra™ Multiplex.

TGR’s CaptSure™ ELISA assay technology underpins Abcam’s growing SimpleStep ELISA range and provides a faster and simpler workflow compared to conventional approaches. TGR’s CaptSure™ technology is available for licensing and collaboration with external parties.

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